Enterprise Architecture: Charting the Territory for Academic Research

The concept of Enterprise Architecture (EA) has long been considered as a means to improve system integration and achieve better IT-business alignment by IT professionals. Recently, the subject gained significant visibility by IS academics. In this paper we provide an overview of existing EA research and practice and present key functions and benefits of EA as seen by IT professionals based on the results of the SIM Information Management Practices Survey. We then identify and discuss directions for future research, including the development of EA definition and nomological net, as well as development of theoretical propositions regarding EA business value

Investigating episodic accretion in a very low-mass young stellar object

Very low-mass Class I protostars have been investigated very little thus far. Variability of these young stellar objects (YSOs) and whether or not they are capable of strong episodic accretion is also left relatively unstudied. We investigate accretion variability in IRS54, a Class I very low-mass protostar with a mass of M$_{\star}$ ~ 0.1 - 0.2 M$_{\odot}$. We obtained spectroscopic and photometric data with VLT/ISAAC and VLT/SINFONI in the near-infrared ($J$, $H$, and $K$ bands) across four epochs (2005, 2010, 2013, and 2014). We used accretion-tracing lines (Pa$\beta$ and Br$\gamma$) and outflow-tracing lines (H$_2$ and [FeII] to examine physical properties and kinematics of the object. A large increase in luminosity was found between the 2005 and 2013 epochs of more than 1 magnitude in the $K$ band, followed in 2014 by a steep decrease. Consistently, the mass accretion rate ($\dot{M}_{acc}$) rose by an order of magnitude from ~ 10$^{-8}$ M$_{\odot}$ yr$^{-1}$ to ~ $10^{-7}$ M$_{\odot}$ yr$^{-1}$ between the two early epochs. The visual extinction ($A_V$) has also increased from ~ 15 mag in 2005 to ~ 24 mag in 2013. This rise in $A_V$ in tandem with the increase in $\dot{M}_{acc}$ is explained by the lifting up of a large amount of dust from the disc of IRS54, following the augmented accretion and ejection activity in the YSO, which intersects our line of sight due to the almost edge-on geometry of the disc. Because of the strength and timescales involved in this dramatic increase, this event is believed to have been an accretion burst possibly similar to bursts of EXor-type objects. IRS54 is the lowest mass Class I source observed to have an accretion burst of this type, and therefore potentially one of the lowest mass EXor-type objects known so far

Advancing the research agenda on food systems governance and transformation

The food systems upon which humanity depends face multiple interdependent environmental, social and economic threats in the 21st Century. Yet, the governance of these systems, which determines to a large extent the ability to adapt and transform in response to these challenges, is underresearched. This perspective piece synthesises the findings of two recent reviews of food systems governance and transformations and proposes a comprehensive research agenda for the coming years. These reviews highlight the influence of governance on food systems, methodological obstacles to explaining the effectiveness of governance in realising food sustainability, and conditions that have historically supported food system transformations. We argue that the following steps are key to improving our knowledge of the role of governance in food systems: (1) developing more comparable research designs for building generalisable explanations of the governance elements that are most effective in realising food systems goals; (2) using the lens of polycentricity to help disentangle complex governance networks; (3) giving greater attention to the conditions and pre-conditions associated with historical food system transformations; (4) identifying adaptations that strengthen or weaken path dependency; and, (5) focusing research on how transformations can be supported by institutions that facilitate collective action and stakeholder agency

The Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions

We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R. equi 103S genome is significantly smaller than those of environmental rhodococci. This is due to genome expansion in nonpathogenic species, via a linear gain of paralogous genes and an accelerated genetic flux, rather than reductive evolution in R. equi. The 103S genome lacks the extensive catabolic and secondary metabolic complement of environmental rhodococci, and it displays unique adaptations for host colonization and competition in the short-chain fatty acid–rich intestine and manure of herbivores—two main R. equi reservoirs. Except for a few horizontally acquired (HGT) pathogenicity loci, including a cytoadhesive pilus determinant (rpl) and the virulence plasmid vap pathogenicity island (PAI) required for intramacrophage survival, most of the potential virulence-associated genes identified in R. equi are conserved in environmental rhodococci or have homologs in nonpathogenic Actinobacteria. This suggests a mechanism of virulence evolution based on the cooption of existing core actinobacterial traits, triggered by key host niche–adaptive HGT events. We tested this hypothesis by investigating R. equi virulence plasmid-chromosome crosstalk, by global transcription profiling and expression network analysis. Two chromosomal genes conserved in environmental rhodococci, encoding putative chorismate mutase and anthranilate synthase enzymes involved in aromatic amino acid biosynthesis, were strongly coregulated with vap PAI virulence genes and required for optimal proliferation in macrophages. The regulatory integration of chromosomal metabolic genes under the control of the HGT–acquired plasmid PAI is thus an important element in the cooptive virulence of R. equi

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points

Boeing Dreamliner:A Project Management Study

The 787 Dreamliner aircraft project required not only the application and integration of new construction materials, it also required new project management techniques for Boeing. By outsourcing most of the aircraft fabrication, Boeing’s primary role changed from designer and manufacturer to system integrator. Hindsight shows that more preparation and planning was needed for this transition. This case study review of the Boeing Dreamliner examines the project management techniques actually employed during the initiation and execution phases of the project. Techniques evolved from the start of the project to what is used currently. Best practices and recommendations for how a large-scale outsourced project could be managed are described. During the initiation phase, Boeing decided to outsource both design and manufacturing. Outsourcing core competencies is a risk to the main contractor’s design and manufacturing edge. The authors recommend selecting those subcontractors with a five step plan, based on selection criteria and culminating with clearly defined expectations. Boeing’s selection was strongly based on cost and market access, and the subcontractor understanding of work expectations initially differed from Boeing’s. It is important to work closely with subcontractors when advanced technology and key components are at stake. Boeing is doing this now, more effectively than at the start. Regular monitoring and control has improved as the project has progressed. Finally, delays and issues show after the fact that Boeing’s early work would have benefited from more robust risk management methods. Risk management techniques are discussed as are improvements Boeing has implemented currently